Symbol
Name
ID

Chd7
chromodomain helicase DNA binding protein 7
MGI:2444748

Phenotype annotations related to reproductive system

Darker colors indicate more annotations

Human Phenotypes	Hypogonadotropic hypogonadism	Labial hypoplasia	Micropenis	Bifid scrotum	Cryptorchidism	Hypoplastic male external genitalia	External genital hypoplasia	Abnormal morphology of female internal genitalia
Disease(s) Associated with CHD7	Hypogonadotropic hypogonadism	Labial hypoplasia	Micropenis	Bifid scrotum	Cryptorchidism	Hypoplastic male external genitalia	External genital hypoplasia	Abnormal morphology of female internal genitalia
CHARGE syndrome
hypogonadotropic hypogonadism 5 with or without anosmia

Mouse Phenotypes

increased granulosa cell apoptosis

decreased primary ovarian follicle number

decreased primordial ovarian follicle number

decreased secondary ovarian follicle number

decreased tertiary ovarian follicle number

increased atretic ovarian follicle number

impaired ovarian folliculogenesis

decreased ovary weight

small ovary

abnormal seminiferous tubule morphology

decreased testis weight

testis hypoplasia

abnormal external female genitalia morphology

clitoris hypoplasia

abnormal uterus morphology

abnormal uterine horn morphology

delayed vaginal opening

delayed fertility

delayed sexual maturation

delayed estrous cycle

abnormal estrous cycle

reduced female fertility

reduced fertility

reduced male fertility

Availability

Mouse Genotype

Chd7^Coa1/Chd7⁺

Chd7^Flo/Chd7⁺

Chd7^{Gt(S20-7E1)Sor}/Chd7⁺

Chd7^Ome/Chd7⁺

Chd7^Whi/Chd7⁺

Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}
Tg(Gdf9-icre)5092Coo/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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